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多机动目标跟踪；多模型；广义标签多伯努利滤波器；多目标混合系统 1

多目标跟踪；广义标签多伯努利；辐射源信号特征；模糊C-均值；动态聚类 1

有监督主题模型；多标签分类；类别频率；有监督隐含狄利克雷分配模型；判别隐含狄利克雷分配模型 1

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p-type transition metal dichalcogenide used for the detection of ultra-trace amounts of diclofenac via a labeledaptasensor

Abdolhamid Hatefi-Mehrjardi, Amirkhosro Beheshti-Marnani, Zarrin Es'haghi

《化学科学与工程前沿（英文）》 2019年第13卷第4期页码 823-831 doi: 10.1007/s11705-019-1797-0

摘要： A -type transition metal dichalcogenide (WS ) was synthesized and hybridized with graphene oxide via a simple hydrothermal method. The as-prepared material was used to modify a glassy carbon electrode for the fabrication of a simple, stable, and repeatable methylene blue-labeled “signal-off” aptasensor used for the sensitive determination of very low amounts of sodium diclofenac (DCF). The synthetic material, modification process, and role of WS in the current response enhancement were studied by X-ray diffraction, energy-dispersive X-ray spectroscopy, field emission scanning electron microscopy, high resolution transmission electron microscopy, Hall effect, cyclic voltammetry, differential pulse voltammetry, and electrochemical impedance spectroscopy. Subsequently, a wide linear range of DCF concentration (0.5–300 nmol/L), very low limit of detection (0.23 nmol/L), and good selectivity were obtained using the differential pulse voltammetry method with the assembled aptasensor. Finally, the fabricated aptasensor was successfully developed for physiological real samples with significant recoveries.

关键词： labeled aptasensor transition metal dichalcogenide graphene oxide sodium diclofenac

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transporter and vesicular monoamine transporter 2 genes for increased retention of metaiodobenzylguanidine labeled

null

《医学前沿（英文）》 2017年第11卷第1期页码 120-128 doi: 10.1007/s11684-017-0501-3

摘要：

Norepinephrine transporter (NET) transfection leads to significant uptake of iodine-131-labeled metaiodobenzylguanidine (¹³¹I-MIBG) in non-neuroendocrine tumors. However, the use of ¹³¹I-MIBG is limited by its short retention time in target cells. To prolong the retention of ¹³¹I-MIBG in target cells, we infected hepatocarcinoma (HepG2) cells with Lentivirus-encoding human NET and vesicular monoamine transporter 2 (VMAT2) genes to obtain NET-expressing, NET-VMAT2-coexpressing, and negative-control cell lines. We evaluated the uptake and efflux of ¹³¹I-MIBG both in vitro and in vivo in mice bearing transfected tumors. NET-expressing and NET-VMAT2-coexpressing cells respectively showed 2.24 and 2.22 times higher ¹³¹I-MIBG uptake than controls. Two hours after removal of ¹³¹I-MIBG-containing medium, 25.4% efflux was observed in NET-VMAT2-coexpressing cells and 38.6% in NET-expressing cells. In vivo experiments were performed in nude mice bearing transfected tumors; results revealed that NET-VMAT2-coexpressing tumors had longer ¹³¹I-MIBG retention time than NET-expressing tumors. Meanwhile, NET-VMAT2-coexpressing and NET-expressing tumors displayed 0.54% and 0.19%, respectively, of the injected dose per gram of tissue 24 h after ¹³¹I-MIBG administration. Cotransfection of HepG2 cells with NET and VMAT2resulted in increased ¹³¹I-MIBG uptake and retention. However, the degree of increase was insufficient to be therapeutically effective in target cells.

关键词： norepinephrine transporter vesicular monoamine transporter 2 -MIBG gene therapy lentivirus vector

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State identification of home appliance with transient features in residential buildings

《能源前沿（英文）》 2022年第16卷第1期页码 130-143 doi: 10.1007/s11708-022-0822-z

摘要： Nonintrusive load monitoring (NILM) is crucial for extracting patterns of electricity consumption of household appliance that can guide users’ behavior in using electricity while their privacy is respected. This study proposes an online method based on the transient behavior of individual appliances as well as system steady-state characteristics to estimate the operating states of the appliances. It determines the number of states for each appliance using the density-based spatial clustering of applications with noise (DBSCAN) method and models the transition relationship among different states. The states of the working appliances are identified from aggregated power signals using the Kalman filtering method in the factorial hidden Markov model (FHMM). Thereafter, the identified states are confirmed by the verification of system states, which are the combination of the working states of individual appliances. The verification step involves comparing the total measured power consumption with the total estimated power consumption. The use of transient features can achieve fast state inference and it is suitable for online load disaggregation. The proposed method was tested on a high-resolution data set such as Labeled hIgh-Frequency daTaset for Electricity Disaggregation (LIFTED) and it outperformed other related methods in the literature.

关键词： nonintrusive load monitoring (NILM) load disaggregation online load disaggregation Kalman filtering factorial hidden Markov model (FHMM) Labeled hIgh-Frequency daTaset for Electricity Disaggregation (LIFTED)

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未知辐射源信号特征辅助的广义标签多伯努利滤波器 Research Article

国强1,滕龙1,2,吴新良2,宋文明2,黄大羽2

《信息与电子工程前沿（英文）》 2022年第23卷第12期页码 1871-1880 doi: 10.1631/FITEE.2200286

摘要：提出一种未知辐射源信号特征辅助的广义标签多伯努利滤波器。复杂电磁环境下，辐射源特征通常未知且随时间变化。针对辐射源特征未知的问题，提出一种基于数据场动态聚类的辐射源特征求解方法。针对辐射源特征时变以及对应的概率分布未知的问题，提出一种改进的模糊C-均值算法来计算目标和杂波量测的相关系数，以近似辐射源特征的似然函数。在此基础上，将辐射源特征集成到广义标签多伯努利滤波器中，从而获得新的递归方程。仿真结果表明，提出的方法可以提高对多目标的跟踪性能，尤其在强杂波环境中。

关键词：多目标跟踪；广义标签多伯努利；辐射源信号特征；模糊C-均值；动态聚类

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多模型广义标签多伯努利滤波器的推导：多目标混合系统解决方案 Research Articles

吴卫华,蔡益朝,金宏斌,郑茂,冯讯,关泽文

《信息与电子工程前沿（英文）》 2021年第22卷第1期页码 1-140 doi: 10.1631/FITEE.2000105

摘要：本文将传统（单目标）混合系统扩展到多目标混合系统，重点研究多机动目标跟踪系统。该系统由连续状态，离散可切换状态以及离散、时不变且唯一性状态组成。通过定义一个新的广义标签多伯努利密度，我们证明对于多目标混合系统，它在查普曼-柯尔莫哥洛夫（Chapman-Kolmogorov）预测和贝叶斯更新下是闭合的。换言之，我们严格推导了多目标混合系统的解决方案，即多模型广义标签多伯努利滤波器——该滤波器虽已被开发，但此前并未得到严格证明。

关键词：多机动目标跟踪；多模型；广义标签多伯努利滤波器；多目标混合系统

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Determination of 27 pharmaceuticals and personal care products (PPCPs) in water: The benefit of isotope dilution

Xueqi Fan, Jie Gao, Wenchao Li, Jun Huang, Gang Yu

《环境科学与工程前沿（英文）》 2020年第14卷第1期 doi: 10.1007/s11783-019-1187-3

摘要： • Isotope dilution method was developed for the determination of 27 PPCPs in water. • The established method was successfully applied to different types of water samples. • The correction effect of corresponding 27 ILSs over 70 d was investigated. • Benefit of isotopic dilution method was illustrated for three examples. Pharmaceuticals and personal care products (PPCPs) are a unique group of emerging and non-persistent contaminants. In this study, 27 PPCPs in various water samples were extracted by solid phase extraction (SPE), and determined by isotope dilution method using liquid chromatography coupled to tandem triple quadruple mass spectrometer (LC-MS/MS). A total of 27 isotopically labeled standards (ILSs) were applied to correct the concentration of PPCPs in spiked ultrapure water, drinking water, river, effluent and influent sewage. The corrected recoveries were 73%–122% with the relative standard deviation (RSD)<16%, except for acetaminophen. The matrix effect for all kinds of water samples was<22% and the method quantitation limits (MQLs) were 0.45–8.6 ng/L. The developed method was successfully applied on environmental water samples. The SPE extracts of spiked ultrapure water, drinking water, river and wastewater effluent were stored for 70 days, and the ILSs-corrected recoveries of 27 PPCPs were obtained to evaluate the correction ability of ILSs in the presence of variety interferences. The recoveries of 27 PPCPs over 70 days were within the scope of 72%–140% with the recovery variation<37% in all cases. The isotope dilution method seems to be of benefit when the extract has to be stored for long time before the instrument analysis.

关键词： Pharmaceuticals and personal care products (PPCPs) Isotopically labeled standard (ILSs) Water Solid-phase extraction (SPE) LC-MS/MS

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词加权有监督主题模型：多标签文本分类 None

Yue-peng ZOU, Ji-hong OUYANG, Xi-ming LI

《信息与电子工程前沿（英文）》 2018年第19卷第4期页码 513-523 doi: 10.1631/FITEE.1601668

摘要：代表性模型包括有监督隐含狄利克雷分配模型（labeled latent Dirichlet allocation，L-LDA）和判别隐含狄利克雷分配模型（dependency-LDA）。

关键词：有监督主题模型；多标签分类；类别频率；有监督隐含狄利克雷分配模型；判别隐含狄利克雷分配模型

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¹³¹I标记的人源化抗B7-H3抗体用于胶质母细胞瘤放射免疫疗法的治疗特性 Article

傅丰庆, Meng Zheng, Shandong Zhao, Yan Wang, Minzhou Huang, Hanqing Chen, Ziyi Huang, Kaijie Zhang, 缪丽燕, 张学光

《工程（英文）》 2023年第30卷第11期页码 190-202 doi: 10.1016/j.eng.2023.05.011

摘要：

B7 homolog 3 (B7-H3) has attracted much attention in glioblastoma (GBM) radioimmunotherapy (RIT) due to its abnormally high expression on tumor cells. In this study, we report that two specific humanized anti-human B7-H3 antibodies (hu4G4 and hu4H12) derived from mouse anti-human B7-H3 antibodies that were generated by computer-aided design and exclusively recognize membrane expression of B7-H3 by human glioma cells. Hu4G4 and hu4H12 were radiolabeled with ⁸⁹Zr for RIT antibody screening. Micro-positron emission tomography (PET) imaging, biodistribution and pharmacokinetic (PK) analyses of ⁸⁹Zr-labeled antibodies were performed in U87-xenografted models. ¹²⁵I labelling of the antibodies for single-photon emission computed tomography (SPECT) imaging was also used to investigate the biological behavior of the antibodies in vivo. Furthermore, the pharmacodynamic (PD) of the 131Ilabeled antibodies were evaluated in U87-xenografted mice and GL261 Red-FLuc-B7-H3 in situ glioma tumor models. Micro-PET imaging and biodistribution analysis with a gamma counter showed that ⁸⁹Zr-deferoxamine (DFO)-hu4G4 had higher tumor targeting performance with lower liver uptake than ⁸⁹Zr-DFO (hu4H12, immunoglobulin G (IgG)). The biodistribution results of ¹²⁵I-SPECT imaging were similar to those of ⁸⁹Zr-PET imaging, though the biodistribution in long bone joints and the thyroid varied. The PD analysis results indicated that 131I-hu4G4 had an excellent therapeutic effect and high safety with no apparent toxicity. Interestingly, 131I-hu4G4 improved the tumor vasculature in tissues with higher expression of collagen type IV and platelet-derived growth factor receptor b (PDGFR-b) compared with control treatment, as determined by immunofluorescence (IF), which contributed to inhibiting tumor growth. Taken together, our data indicate that hu4G4 exhibits good tumor targeting and specificity, achieves low nonspecific concentrations in normal tissues, and has acceptable PK characteristics. 131I-hu4G4 also exerts effective antitumor effects with an ideal safety profile. Therefore, we expect hu4G4 to be an excellent antibody for the development of GBM RIT.

关键词： B7-H3 Radioimmunotherapy Glioblastoma Pharmacokinetics Pharmacodynamics